Isotretinoin l0mg & 20mg/capsule.

Isotretinoin is an isomer of tretinoin, & tretinoin is the acid form of vitamin-A.

Ind: Acne vulgaris, specially modulo-cystic & conglobate acne, & severe acne resistant to previous treatment with antibiotics; & also treatment of late onset acne in women in the third or fourth decades of life, because they are mostly resistant to amibiotic therapy.

C/I: Pregnancy & lactation. Hepatic & renal insufficiency. Hypervitaminosis A. Patients with excessively elevated blood lipid values. Hypersensitivity to the drug. Supplementary treatment with tetracyclines. Blood donation by the patients who are being treated or who have recently been treated (1 to 2 weeks before) with isotretinoin is contraindicated to the women of childbearing ages.

S/E: Muscle and joint pain. Bone changes in children & adults and hyperostosis in children (i.e premature epiphyseal closure) occur when treated with high doses of isotretinoin over long periods. Psychic or neurological disturbances. Hyperlipidaemia & hypertriglyceridaemia. Dermatitis facialis, pyogenic granuloma, paronychia, increased formation of granulation tissue. Reversible alopecia. Intolerance to contact lenses & decreased night vision.

Precautions: Liver functions & serum lipids (fasting value) should be checked before starting treatment. In diabetics, frequent determination of blood glucose levels is recommended.

Pregnancy & lactation: Isotretinoin is highly teratogenic, & must not be used by the women who are pregnant & also women of childbearing potential unless strict contraception is practised four weeks before, during, & one month after treatment. It also must not be given to nursing mother.

Dosage & admin: Treatment should be started with 0.5mg/kg daily. After about 4 weeks of treatment, maintenance dose should be adjusted within the range of 0.1-lmg/kg daily to meet individual needs. The maximum dose of lmg/kg daily should be given for only a limited period of time. Maximum treatment duration- 5 months.

Drug inter: Concurrent therapy with isotretinoin & vitamin A must be avoided. l0mg x 30's pack: 2,250.00 TP